Figure 7.

Ets-1 is localized within a QTL on chromosome 8 that associates with kidney injury. Genome scan (at chromosome 8) for SBP, UPE, UAE, KLG, HW, and TKW at 8, 12, and 16 weeks of age for the backcross population (n=228) raised on a 2% NaCl diet. Significant increases of UPE, UAE, and KLG (right) are correlative to the QTLs of chromosome 8 (left). ETS-1 is at this critical area, according to its chromosome position. HW, heart weight; UPE, urinary protein excretion; UAE, urinary albumin excretion; TKW, total kidney weight; KLG, kidney lesion grade. The bar represented 20 centiMorgan (cM). Modified from reference 15, with permission.