Table 3.
Risk of heart failure associated with GSTM1 copy number (n=5368)
| Hazard Ratio (95% Confidence Interval) | |||||||
|---|---|---|---|---|---|---|---|
| Model | Genotypic Model (by GSTM1 Copy Number) | Dominant Genetic Model | |||||
| 0 Copy | 1 Copy | 2 Copies | P for Trend | 0 or 1 Copy versus 2 Copies | P Value | LRT P Value | |
| White cohort | |||||||
| Model 1 | 1.14 (0.96 to 1.35) | 1.17 (0.98 to 1.39) | Reference | 0.43 | 1.15 (0.97 to 1.36) | 0.11 | 0.62 |
| Model 2 | 1.16 (0.97 to 1.38) | 1.18 (0.99 to 1.42) | Reference | 0.31 | 1.17 (0.98 to 1.39) | 0.07 | 0.69 |
| Black cohort | |||||||
| Model 1 | 1.05 (0.88 to 1.25) | 1.15 (0.99 to 1.33) | Reference | 0.56 | 1.12 (0.97 to 1.28) | 0.12 | 0.22 |
| Model 2 | 1.04 (0.87 to 1.23) | 1.18 (1.02 to 1.36) | Reference | 0.63 | 1.13 (0.98 to 1.30) | 0.09 | 0.25 |
| Overall | |||||||
| Model 1 | 1.09 (0.97 to 1.23) | 1.15 (1.03 to 1.29) | Reference | 0.38 | 1.13 (1.01 to 1.25) | 0.03 | 0.24 |
| Model 2 | 1.12 (0.99 to 1.26) | 1.20 (1.07 to 1.34) | Reference | 0.32 | 1.16 (1.04 to 1.29) | <0.01 | 0.13 |
Model 1: age, sex, center, and ten genetic principal components. Model 2: model 1 plus prevalent diabetes, hypertension, coronary heart disease, smoking status, BMI, and eGFR. Race was included as a covariate in the combined analysis. Likelihood ratio test (LRT) was conducted to assess whether significant difference existed between the genotypic model and the dominant genetic model.