Table 3.
Multivariate correlates of dnDSA development: Subset with histology 0–12 mo post-transplant
| Subset with Histology 0–12 mo Post-Transplant | DR dnDSA n=439, 29 Events | DQ dnDSA n=439, 48 Events | DR or DQ dnDSA n=439, 63 Events | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Recipient age at transplant, yr | 0.98 (0.96 to 1.00) | 0.09 | 0.97 (0.96 to 0.99) | 0.003 | 0.98 (0.96 to 0.99) | 0.003 |
| Nonadherence | 3.38 (1.53 to 7.28) | 0.003 | 3.78 (2.08 to 6.79) | <0.001 | 3.28 (1.93 to 5.51) | <0.001 |
| HLA-DRβ1/3/4/5 eplet mismatch/ten mismatches | 3.16 (1.96 to 5.24) | <0.001 | ||||
| HLA-DQα1/β1 eplet mismatch/ten mismatches | 1.46 (1.12 to 1.93) | <0.001 | ||||
| HLA-DRβ1/3/4/5 + HLA-DQα1/β1 eplet mismatch/ten mismatches | 1.34 (1.14 to 1.57) | 0.003 | ||||
| TCMR greater than or equal to borderline in 0–12 mo | 1.37 (1.08 to 1.69) | 0.01 | 1.31 (1.08 to 1.56) | 0.001 | 1.22 (1.03 to 1.43) | 0.02 |