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. 2017 Oct 30;4(5):ENEURO.0323-17.2017. doi: 10.1523/ENEURO.0323-17.2017

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Copyright © 2017 Solis et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 1. — Changes in NAc oxygen levels (normalized as percentage vs baseline = 100%) induced by intravenous injections of fentanyl (40 µg/kg; A), heroin (400 µg/kg; B), and their mixture (40 µg/kg fentanyl + 360 µg/kg heroin; B) in awake, freely moving rats. Changes in NAc oxygen were significant for each of the three treatments. Values significantly different from baseline (p < 0.05; horizontal hatched lines) are shown as filled symbols. Moment of drug injection (time = 0 min) is shown as vertical hatched line. C, Mean values of three parameters of oxygen response [peak amplitude, s; latency to peak, s; and area under the curve for the total oxygen decrease (AUC)]. Asterisks denote significant between-group differences (p < 0.05). Symbols in peak amplitude graph show individual values of oxygen decreases in percentage of baseline.