Table II.
Univariate analyses of recurrence-free survival with respect to treatment characteristics.
| Estimated RFS rate, % (95% CI) | ||||||
|---|---|---|---|---|---|---|
| Variable | Total no. of patients | No. of patients with recurrences | 1-year | 2-year | 5-year | P-value (log-rank)a |
| Margin status after primary resection | ||||||
| R0 | 50 | 34 | 87.9 (75.0–94.4) | 75.5 (60.8–85.3) | 68.8 (53.5–79.9) | |
| R1/2 | 40 | 11 | 72.5 (55.9–83.7) | 55.0 (38.5–68.8) | 34.1 (19.9–48.9) | 0.001b |
| R1 | 28 | 7 | 71.4 (50.9–84.6) | 46.4 (27.6–63.3) | 28.6 (13.5–45.6) | <0.001c |
| R2 | 12 | 4 | 75.0 (40.8–91.2) | 75.0 (40.8–91.2) | 47.6 (18.2–72.4) | 0.341d |
| Distance of closest negative surgical margin at resection of the primary tumor (R0 group), mm | ||||||
| ≤1 | 26 | 16 | 84.4 (63.7–93.9) | 76.2 (54.4–88.6) | 62.9 (40.5–78.8) | 0.301e |
| >1 | 24 | 18 | 91.7 (70.6–97.8) | 75.0 (52.6–87.9) | 75.0 (52.6–87.9) | |
| ≤5 | 44 | 31 | 88.5 (74.6–95.1) | 79.1 (63.6–88.5) | 71.5 (55.2–82.7) | 0.245f |
| >5 | 6 | 3 | 83.3 (27.3–97.5) | 50.0 (11.1–80.4) | 50.0 (11.1–80.4) | |
| Wound closure after primary resection | 0.069 | |||||
| Primary closure | 69 | 31 | 78.1 (66.4–86.2) | 60.2 (47.6–70.7) | 47.0 (34.4–58.6) | |
| Non-primary closure (plastic surgical tissue transfer) | 21 | 14 | 90.5 (67.0–97.5) | 85.7 (62.0–95.2) | 69.3 (43.6–85.1) | |
| Adjuvant radiotherapy | 0.861 | |||||
| Yes | 27 | 13 | 81.5 (61.1–91.8) | 73.9 (52.9–86.6) | 48.4 (27.8–66.3) | |
| No | 63 | 32 | 80.8 (68.7–88.6) | 63.0 (49.8–73.7) | 54.4 (41.1–65.9) | |
| Adjuvant NSAID treatment | 0.080 | |||||
| Yes | 19 | 7 | 73.7 (47.9–88.1) | 47.4 (24.4–67.3) | 36.8 (16.5–57.5) | |
| No | 71 | 38 | 83.0 (72.1–90.0) | 71.5 (59.4–80.6) | 56.9 (44.0–67.8) | |
| Margin status after last resection in patients with ≥1 recurrence | 0.269 | |||||
| R0 | 25 | 11 | 87.6 (66.3–95.8) | 77.9 (54.5–90.2) | 77.9 (54.5–90.2) | |
| R1/R2 | 20 | 12 | 89.2 (63.1–97.2) | 77.6 (50.7–91.0) | 50.2 (24.0–71.6) | |
a
Log-rank test for equality of survivor functions
b
R0 vs. R1/2
c
R0 vs. R1
d
R1 vs. R2
e
≤1 vs. >1 mm
f
≤5 vs. >5 mm. RFS, recurrence-free survival; CI, confidence interval; NSAID, non-steroidal anti-inflammatory drug.