Table III.

Cox proportional hazard models on the overall survival rate of lung AC patients.

	Univariate analysis		Multivariate analysis
Factor	P-value	HR (95% CI)	P-value	HR (95% CI)
Gender (male vs. female)	0.983	1.005 (0.616–1.640)	0.855	0.922 (0.386–2.202)
Age, years (<63 vs. ≥63)	0.055	0.618 (0.378–1.010)	0.115	2.287 (0.817–6.402)
MCT-4 expression (low vs. high)	0.000	3.267 (1.851–5.767)	0.001	3.192 (1.804–5.646)
Invasion depth (T1/2 vs. T3/4)	0.026	0.501 (0.272–0.921)	0.314	1.433 (0.711–2.887)
Lymph node metastasis (N0 vs. N1/2/3/X)	0.018	0.554 (0.340–0.904)	0.057	0.272 (0.071–1.041)
Distant metastasis (M0 vs. M1)	0.948	1.048 (1.048–4.288)	0.633	0.821 (0.365–1.847)
TNM stage (I/II vs. III/IV)	0.005	2.150 (1.258–3.674)	0.007	2.084 (1.217–3.569)
Histological type (invasive AC vs. variant invasive AC)	0.627	1.215 (0.554–2.663)	0.431	0.502 (0.090–2.791)

AC, adenocarcinoma; HR, hazard ratio; CI, confidence interval; MCT-4, monocarboxylate transporter 4.