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. 2017 Sep 8;14(5):5845–5852. doi: 10.3892/ol.2017.6914

Table IV.

MVD (detected by IHC of CD34) and miR-10b expression (detected by ISH) with clinicopathologic features of 195 cases.

MVD miR-10b
Indicator Number Mean ± SD P-value Positive number Positive rate P-valuec r P-valued
Age
  <35 5 37.60±8.26 3 60.0
  35 to <49 94 39.2±14.50 63 67.0
  >50 96 37.1±14.61 0.796a 49 51.0 0.057 −0.146 0.042
Grade
  Grade 1 26 35.4±12.32 14 53.8
  Grade 2 128 37.3±14.58 69 53.9
  Grade 3 41 43.8±14.00 0.023a 32 78.0 0.020 0.168 0.019
Tumor size
  T1a+T1b 5 31.20±13.52 0 0
  T1c 51 37.67±12.94 26 51.0
  T2 126 38.44±15.2 80 63.5
  T3 13 44.77±10.22 0.271a 9 69.2 0.015 0.175 0.014
Peritumoural vascular invasion
  Absent 175 36.92±13.37 101 57.7
  Present 20 52.10±16.20 <0.001a 14 70.0 0.290 0.076 0.292
Molecular subtype
  ‘Luminal A-like’ 59 32.69±10.86 16 27.1
  ‘Luminal B-like (HER2 negative)’ 41 36.78±13.03 27 65.9
  ‘Luminal B-like (HER2 positive)’ 21 38.29±15.00 16 76.2
  ‘HER2 positive’ 23 38.74±11.78 18 78.3
  ‘Triple negative’ 51 46.49±16.52 <0.001b 38 74.5 <0.001 0.011 0.875
miR-10b expression
  Positive 115 42.40±14.05
  Negative 80 32.84±13.02 <0.001a MVD   0.370 <0.001
a

P-values were calculated by ANOVA test. The sequence of the different grade: Grade 1 = grade 2 (P=0.520) < grade 3 (P=0.013) (multiple comparision in ANOVA).

b

Comparison of MVD in 5 molecular subtypes: P-values were calculated by Kruskal-Wallis test (λ2=21.79); luminal A < triple negative (P<0.001, Mann-Whitney U test).

c

P-values were calculated by χ2 test. The sequence of the different grade: Grade 1 = grade 2 (P=0.9967) < grade 3 (P=0.006<0.017, subdividing RxC table in χ2 test); the sequence of the different tumor size: T1a and T1b<T2 (P=0.017<0.008, subdividing RxC table in χ2 test); the sequence of the different subtypes: Luminal A < luminal B (P<0.001<0.005) = triple negative (P=0.365) = luminal HER2 (P=0.881) = HER2 enriched (P=0.870) (subdividing RxC table in χ2 test).

d

P-values were calculated by Spearman's rank-correlation test (n=195). Bold values indicate statisical significane where P<0.05. MVD, microvessel density; IHC, immunohistochemical; ISH, in situ hybridization; HER2, human epidermal growth factor receptor 2.