Table IV.
MVD | miR-10b | |||||||
---|---|---|---|---|---|---|---|---|
Indicator | Number | Mean ± SD | P-value | Positive number | Positive rate | P-valuec | r | P-valued |
Age | ||||||||
<35 | 5 | 37.60±8.26 | 3 | 60.0 | ||||
35 to <49 | 94 | 39.2±14.50 | 63 | 67.0 | ||||
>50 | 96 | 37.1±14.61 | 0.796a | 49 | 51.0 | 0.057 | −0.146 | 0.042 |
Grade | ||||||||
Grade 1 | 26 | 35.4±12.32 | 14 | 53.8 | ||||
Grade 2 | 128 | 37.3±14.58 | 69 | 53.9 | ||||
Grade 3 | 41 | 43.8±14.00 | 0.023a | 32 | 78.0 | 0.020 | 0.168 | 0.019 |
Tumor size | ||||||||
T1a+T1b | 5 | 31.20±13.52 | 0 | 0 | ||||
T1c | 51 | 37.67±12.94 | 26 | 51.0 | ||||
T2 | 126 | 38.44±15.2 | 80 | 63.5 | ||||
T3 | 13 | 44.77±10.22 | 0.271a | 9 | 69.2 | 0.015 | 0.175 | 0.014 |
Peritumoural vascular invasion | ||||||||
Absent | 175 | 36.92±13.37 | 101 | 57.7 | ||||
Present | 20 | 52.10±16.20 | <0.001a | 14 | 70.0 | 0.290 | 0.076 | 0.292 |
Molecular subtype | ||||||||
‘Luminal A-like’ | 59 | 32.69±10.86 | 16 | 27.1 | ||||
‘Luminal B-like (HER2 negative)’ | 41 | 36.78±13.03 | 27 | 65.9 | ||||
‘Luminal B-like (HER2 positive)’ | 21 | 38.29±15.00 | 16 | 76.2 | ||||
‘HER2 positive’ | 23 | 38.74±11.78 | 18 | 78.3 | ||||
‘Triple negative’ | 51 | 46.49±16.52 | <0.001b | 38 | 74.5 | <0.001 | 0.011 | 0.875 |
miR-10b expression | ||||||||
Positive | 115 | 42.40±14.05 | ||||||
Negative | 80 | 32.84±13.02 | <0.001a | MVD | 0.370 | <0.001 |
P-values were calculated by ANOVA test. The sequence of the different grade: Grade 1 = grade 2 (P=0.520) < grade 3 (P=0.013) (multiple comparision in ANOVA).
Comparison of MVD in 5 molecular subtypes: P-values were calculated by Kruskal-Wallis test (λ2=21.79); luminal A < triple negative (P<0.001, Mann-Whitney U test).
P-values were calculated by χ2 test. The sequence of the different grade: Grade 1 = grade 2 (P=0.9967) < grade 3 (P=0.006<0.017, subdividing RxC table in χ2 test); the sequence of the different tumor size: T1a and T1b<T2 (P=0.017<0.008, subdividing RxC table in χ2 test); the sequence of the different subtypes: Luminal A < luminal B (P<0.001<0.005) = triple negative (P=0.365) = luminal HER2 (P=0.881) = HER2 enriched (P=0.870) (subdividing RxC table in χ2 test).
P-values were calculated by Spearman's rank-correlation test (n=195). Bold values indicate statisical significane where P<0.05. MVD, microvessel density; IHC, immunohistochemical; ISH, in situ hybridization; HER2, human epidermal growth factor receptor 2.