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. 2017 Oct 24;12:7763–7776. doi: 10.2147/IJN.S149306

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© 2017 Santiago et al. This work is published and licensed by Dove Medical Press Limited

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The general procedure for the multifunctionalization of 50 nm AuNPs with GEM and subsequently TF via EDC/NHS coupling to MBA and PATP, respectively, forming pH-sensitive amide bonds.

Abbreviations: AuNPs, gold nanoparticles; EDC, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride; FA, folic acid; GEM, gemcitabine; MBA, mercaptobenzoic acid; NHS, N-hydroxysuccinimide; PATP, p-aminothiophenol; TF, transferrin.