Figure 6.
(A and B) Normalized spectra for fully loaded AuNP@MBA,PATP/GEM,FA nanocarriers in buffer solutions with pH (A) 7.4 and (B) 5.5, recorded at the starting time (1), after 60 min exposure to the buffer, marked (2), and after 120 min of exposure (3); P1 and P2 are Raman bands at 1,586 and 1,074 cm−1, respectively. (C) Temporal evolution of GEM release in solution of pH (1) 7.4 and (2) 5.5. The release function R was determined from the SERS signal of the Raman marker at 1,586 cm−1.
Abbreviations: AuNP, gold nanoparticle; FA, folic acid; GEM, gemcitabine; MBA, mercaptobenzoic acid; PATP, p-aminothiophenol; SERS, surface-enhanced Raman scattering.