Table III.
Multivariate analyses of characteristics associated with OS and DFS.
| OS (n=293) | DFS (n=268) | |||||
|---|---|---|---|---|---|---|
| Variables | HR | 95% CI | P-valuea | HR | 95% CI | P-valuea |
| T stage | 0.008 | <0.001 | ||||
| T1 | RV | – | – | RV | – | – |
| T2 | 2.356 | 1.380–4.021 | 0.002 | 2.516 | 1.155–5.483 | 0.020 |
| T3 | 2.406 | 1.200–4.824 | 0.013 | 2.735 | 1.542–4.853 | 0.001 |
| T4 | 3.319 | 0.885–12.447 | 0.075 | 8.353 | 2.457–28.393 | 0.001 |
| Distant metastasis | ||||||
| Yes vs. no | 3.534 | 1.841–6.784 | <0.001 | – | – | – |
| Fuhrman grade | 0.002 | <0.001 | ||||
| 1–2 | RV | – | – | RV | – | – |
| 3 | 2.230 | 1.298–3.832 | 0.004 | 2.839 | 1.553–5.190 | 0.001 |
| 4 | 4.125 | 1.182–14.401 | 0.026 | 4.810 | 1.342–17.242 | 0.016 |
| Necrosis | ||||||
| Present vs. absent | 2.010 | 1.151–3.511 | 0.014 | 2.087 | 1.177–3.701 | 0.012 |
| ECOG PS | 0.005 | 0.012 | ||||
| 0 | RV | – | – | RV | – | – |
| 1 | 2.130 | 1.301–3.487 | 0.003 | 1.957 | 1.115–3.434 | 0.019 |
| 2 | 2.310 | 0.789–6.760 | 0.126 | 3.233 | 0.980–10.667 | 0.054 |
| 3 | 3.514 | 1.169–10.568 | 0.025 | 3.236 | 1.048–9.993 | 0.041 |
| Tumor CTR1 expression | ||||||
| Low vs. high | 2.291 | 1.389–3.777 | 0.001 | 2.210 | 1.299–3.759 | 0.003 |
a
Data obtained from the Cox proportional hazards model. P<0.05 was regarded as statistically significant. OS, overall survival; DFS, disease-free survival; HR, hazard ratio; CI, confidence interval; RV, reference value; CTR1, copper transporter 1.