Table 1.

Current guideline recommendations for the use of combination urate-lowering therapy

Organization	Year	Recommendation
ACR4	2012	Combination oral urate-lowering therapy with xanthine oxidase inhibitor agent and uricosuric agent is appropriate when the serum urate target has not been met by appropriate dosing of a xanthine oxidase inhibitor.
EULAR5	2017	If the serum urate target cannot be reached by an appropriate dose of APL, APL should be switched to FBX or a uricosuric or combined with a uricosuric.
BSR1	2017	A uricosuric agent can be used in combination with a xanthine oxidase inhibitor in patients who do not achieve a therapeutic serum urate target with optimal doses of monotherapy.

Abbreviations: ACR, American College of Rheumatology; APL, allopurinol; BSR, British Society of Rheumatology; EULAR, European League against Rheumatism; FBX, feboxustat.