Table 2.
Molecular function annotation enrichment results comparing sham versus V-SNI
| No. | Term | P-value | Genes |
|---|---|---|---|
| 1 | Heparin binding | 0.001499866 | VEGFB, FGFR4, CCL2, NAV2, CCL5, CCL7, ITGAM, ABI3BP, CXCL10, CYR61 |
| 2 | Chemokine activity | 0.001548949 | CCL2, CCL19, CCL5, CXCL12, CCL7, CXCL10 |
| 3 | Protein binding | 0.001837527 | PRX, SGSH, RHOJ, HSP90AB1, APOBEC3, HPS5, CLSTN3, USH1G, PAX6, RHOQ, ANKRD1, JAG1, CXADR, CD96, NOD1, CD44, RAVER2, ANK3, HOMER3, ATG7, SERPINE1, SPG20, ANO2, PIK3AP1, PILRA, EGFR, DYNC1I1, RBFOX2, SH3PXD2A, LYN, CCDC88C, RXRB, FMR1, ZFP467, SIX3, PDXP, BICD2, PPARGC1B, PDCD1LG2, CARD11, ARVCF, DSG1A, CD36, ZFAND2B, ROR2, H2-AA, VGLL2, FLII, CD226, CD300LD, ABCA7, FGFR4, NKD1, IL1R1, CCL2, RAB3D, PRTN3, CD247, CNTFR, CHEK1, ITGB2, BCL2L2, PAXBP1, CBLL1, TCF7L2, CTLA2B, MOV10, STAT4, GFI1, NFATC2, TCF3, PXT1, LRFN2, HAVCR2, FYB, EIF4ENIF1, CR2, TRNP1, TGFBR2, EN1, DOCK7, AMBRA1, IDO1, HS1BP3, VAV1, PPP1R13L, DVL1, SYNE3, EPHA4, LCE1G, EPS8, CMYA5, CYFIP2, MILR1, CIT, BMPR1B |
| 4 | Chemokine receptor binding | 0.003686081 | CCL19, CCL5, S100A14, CXCL12 |
| 5 | Cytokine activity | 0.004934124 | IL17A, CCL2, C1QTNF4, IFNE, IL17F, TNFSF12, INHA, CCL5, CXCL12, CCL7, CXCL10 |
| 6 | Serine-type peptidase activity | 0.008639921 | TMPRSS11G, PRTN3, CFB, CTRB1, TYSND1, DPP8, CFI, TMPRSS12, HABP2 |
| 7 | Transmembrane receptor protein tyrosine kinase activity | 0.015247211 | EGFR, EPHA4, FGFR4, LTK, ROR2 |
| 8 | Spectrin binding | 0.017147753 | DYNC1I1, DMTN, ANK3, USH1G |
| 9 | Guanyl-nucleotide exchange factor activity | 0.021272918 | FGD2, DOCK2, CYTH4, PSD4, DOCK7, VAV1, EIF2B3, RGL1 |
| 10 | G-protein-coupled receptor binding | 0.026730704 | GNA14, GNA15, CCL2, DNAJC14, USP20 |
| 11 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 0.027051751 | PAX6, ZFP467, EN1, PAXBP1, FOSB, TCF7L2, FEZF2, SMARCD2, PRDM5, ZFP219, NFATC2, TCF3, NFIA |
| 12 | Transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | 0.027375039 | STAT6, PRDM5, ZFP219, EN1, GFI1, NFATC2, TCF3 |
| 13 | Integrin binding | 0.032537287 | EGFR, LYN, ITGA2, CXADR, CD226, CYR61 |
| 14 | Serine-type endopeptidase activity | 0.035490515 | TMPRSS11G, F5, PRTN3, CFB, CTRB1, TYSND1, CFI, TMPRSS12, HABP2 |
| 15 | GTP binding | 0.040618394 | HSP90AB1, RHOJ, GNA14, GNA15, RAB3D, TUBA3B, RHOQ, RAB40C, NPR2, 1700009N14RIK, RND1, TUBB6, NKIRAS2 |
Abbreviations: SNI, spared nerve injury; V-SNI, group that repeated vehicle injections before and after SNI.