Table 3.
Molecular function annotation enrichment results comparing V-SNI versus MC-SNI
| No. | Term | P-value | Genes |
|---|---|---|---|
| 1 | Actin binding | 0.002751885 | TNNT3, TRIOBP, SHROOM3, TNNC2, SYNPO2, MYOZ1, MYOZ2, TPM4, FLNA, TNNI2 |
| 2 | Serine-type endopeptidase activity | 0.010409829 | MMP8, GM2663, LTF, 2210010C04RIK, MCPT2, TMPRSS12, CTSG |
| 3 | Metalloendopeptidase activity | 0.022158153 | ADAM28, ADAMTS9, ADAM29, MMP8, PMPCB |
| 4 | Hydrolase activity | 0.041880873 | APOBEC2, ADAM28, APOBEC3, CPPED1, PTPRN2, MMP8, PTPN14, PGAM2, MCPT2, MTMR2, NT5C3, PLA2G12A, ACOT11, VPS4B, ATP8B1, PARG, LTF, TMPRSS12, HDAC8, CTSG, PMPCB |
| 5 | FATZ binding | 0.042538506 | APOBEC2, APOBEC3 |
| 6 | Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines | 0.042538506 | MYOZ1, MYOZ2 |
| 7 | Guanyl–nucleotide exchange factor activity | 0.046446397 | FGD2, DENND5A, RAPGEF6, DOCK7, DENND4B |
| 8 | Metallopeptidase activity | 0.050491587 | ADAM28, ADAMTS9, ADAM29, MMP8, PMPCB |
| 9 | Telethonin binding | 0.050827978 | MYOZ1, MYOZ2 |
| 10 | Catalytic activity | 0.056869731 | APOBEC2, XDH, APOBEC3, SPTLC2, CKMT2, ABAT, PGAM2, PCYT1B, PMPCB |
Abbreviations: MC-SNI, group that had minocycline repeatedly administered before and after SNI; SNI, spared nerve injury; V-SNI, group that repeated vehicle injections before and after SNI.