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. 2017 Feb 10;2:16035. doi: 10.1038/sigtrans.2016.35

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Copyright © 2017 The Author(s)

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Butyrate inhibits complex I by inhibiting SIRT3. (a) Butyrate and NAM/TSA treatment inactivates complex I. Complex I activity was measured in lysates of either HeLa or HEK293T cells with and without butyrate or NAM/TSA treatment. (b) Butyrate-mediated inhibition of complex I activity is dependent on SIRT3. Complex I activity was measured in lysates of HeLa cells after SIRT3 knockdown and silent mutated SIRT3 (SIRT3*) reintroduction through transfection. The SIRT3 expression levels were shown in the right panel.