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. 2017 Feb 17;2:16044. doi: 10.1038/sigtrans.2016.44

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Copyright © 2017 The Author(s)

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After 70% partial hepatectomy (PH), platelets harboring VEGF-A and SDF-1 are associated with VEGFR3⁺ LSECs. (a, b) Liver sections were stained with antibodies to CD41 (green), VEGF-A and SDF-1 (red), and VEGFR3 (gray). After PH, but not sham operation (Sham), CD41⁺SDF-1⁺VEGF-A⁺ platelets are associated with VEGFR3⁺ LSECs. Scale bar, 50 μm. (c, d) BrdU incorporation in hepatocyte (c) and liver mass restoration (d) in Thpo^−/− and WT mice at days 2 and 8 after PH, respectively. ^#P<0.05, compared to control group; N=5–8 mice per group.