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. 2017 Aug 18;2:17036. doi: 10.1038/sigtrans.2017.36

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Copyright © 2017 The Author(s)

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Redox regulation of cytoskeleton remodeling. Cys374 of β-actin can be oxidized in response to oxidative stress, leading to decreased actin polymerization and enhanced cytoskeleton remodeling. Mical promotes the oxidation of β-actin, whereas Trx and SelR mediate the reduction of β-actin. In addition, tubulin can also be regulated by ROS. ROS promote the formation of tubulin tetramers, leading to cytoskeletal injury. Moreover, ROS can also affect the formation of lamellipodia by inhibiting the activity of 14-3-3ζ. Once oxidized, the inhibitory effect of 14-3-3ζ on SSH-1L will be alleviated, ultimately leading to the formation of the cofilin-actin rod and lamellipodia. Trx, thioredoxin; ROS, reactive oxygen species; SSH-1L, Slingshot-1L; NOX4, NADPH oxidase 4; 5-LOX, 5-lipoxygenase.