Table 2. Synergism analysis for CNL and ibrutinib co-treatment in JVM-3 cells.

CNL dose	Ibrutinib dose	Cell viability	Combination index	Effect
5 μM	1 μM	83%	0.81	Synergism
5 μM	2.5 μM	79%	0.66	Synergism
10 μM	1 μM	53%	0.53	Synergism
10 μM	2.5 μM	42%	0.38	Synergism

Treatment with ibrutinib alone at 1 and 2.5 μM for 24 h did not affect cell viability. Twenty-four hours treatment with CNL at 5 and 10 μM reduced cell viability to 90% and 70%, respectively.