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. 2016 Mar 11;1:16002. doi: 10.1038/sigtrans.2016.2

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Copyright © 2016 West China Hospital, Sichuan University

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Responses of the special lesions to Chimeric Antigen Receptor-modified T-20 (CART-20) cells. (a) The skin lesions of patient UPN09 completely disappeared, and the disappearance lasted up to 10 months or more, despite continued splenomegaly. (b) The new lesions in the testes of patient UPN02 emerged at 6 months after infusion. (c) Immunohistochemical examination of a needle biopsy of lesions in the testis from patient UPN02 at 6 months after CART-20 cell infusion showed that the tumor cells were CD20⁺, CD3⁻, CD4⁻, and CD8⁻. (d) The CART-20 cells in the peripheral blood, cerebral spinal fluid (CSF) and the testis of patient UPN02 were measured by quantitative real-time-PCR at 6 months after CART-20 cell infusion. PB, peripheral blood cells.