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. 2016 Mar 11;1:16002. doi: 10.1038/sigtrans.2016.2

Table 1. Patient characteristics and response summary.

Subject number /gender/age Diagnosis/subtypes Stage of disease at first diagnosis IPI/aaIPI The prior therapies Disease status at study entry Conditioning therapy CAR20 kg −1 (×10 7 ) Disease response to CART cells PFS(m)
UPN01/M/53a DLBCL/ABC IIISB 2 R-CHOP×5, R-ESHAP×2 SD None 0.69 CR 13+
UPN02/M/57b DLBCL/ABC IVA 3 R-CHOP×7 PD CHOP 0.90 PR 6
UPN03/M/25b DLBCL/ABC IV/XA 3 CHOP, R-CHOP, R-ICE×3, R-COEP and Auto-HSCT PD MACH 0.53 CR 4
UPN04/F/64a DLBCL/ABC IIA 3 R-CHOP×6 PD FC 0.41 PR 2
UPN05/M/36a DLBCL/ABC IVA 4 R-CHOP×6, Radiotherapy and R-GDP×3, GDP, DICE×3 PD EOCH 0.90 SD 2
UPN06/M/44a , c DLBCL/NOS IIA 2 CHOP×6, R-CHOP×2, R-ESHAP SD CHOD 0.48 PR (2+11)13+
UPN07/F/46a , d FL IVA 3 R-CHOP×5, R-FC PD None 0.93 CR 5
UPN08/M/49a , e MCL IIIA 3 R-Hyper-CVAD×5 SD None 1.01 CR 5
UPN09/M/63a , c , d PCMZL IVSA 3 R-CHOP×4, DICE PD CHODE 1.46 SD (3+10)13+
UPN10/M/64a DLBCL/ABC IIB 3 R-CHOP×2 PR CHOP 1.29 CR 6+
UPN11/M/70a , f DLBCL/GCB IIIXB 3 R-CHOP×5, R-ICE×2, R-ESHAP×2 and Radiotherapy PR None 0.47 CR (16+11)27+

Abbreviations: ABC, activated-B-like-cell; CART, Chimeric Antigen Receptor-modified T cells; CR, complete remission; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; GCB, germinal center B-cell origin; MCL, mantle cell lymphoma; PCMZL, primary cutaneous marginal zone lymphoma; PD, disease progression; PFS, progression-free survival; PR, partial remission; SD, stable disease.

a

Refractory.

b

Relapsing.

c

UPN06 and UPN09 received local radiotherapy at 2 and 3 months after infusion respectively, then they both got complete remission.

d

Bone marrow involvement.

e

Lost to follow-up because patient refused to come to appointments.

f

CART-20 infusion again in phase IIa trail after 16-month CR from our phase I trial.

+ indicates an ongoing response as of the time of manuscript submission.