Table 1. Patient characteristics and response summary.
| Subject number /gender/age | Diagnosis/subtypes | Stage of disease at first diagnosis | IPI/aaIPI | The prior therapies | Disease status at study entry | Conditioning therapy | CAR20 kg −1 (×10 7 ) | Disease response to CART cells | PFS(m) |
|---|---|---|---|---|---|---|---|---|---|
| UPN01/M/53a | DLBCL/ABC | IIISB | 2 | R-CHOP×5, R-ESHAP×2 | SD | None | 0.69 | CR | 13+ |
| UPN02/M/57b | DLBCL/ABC | IVA | 3 | R-CHOP×7 | PD | CHOP | 0.90 | PR | 6 |
| UPN03/M/25b | DLBCL/ABC | IV/XA | 3 | CHOP, R-CHOP, R-ICE×3, R-COEP and Auto-HSCT | PD | MACH | 0.53 | CR | 4 |
| UPN04/F/64a | DLBCL/ABC | IIA | 3 | R-CHOP×6 | PD | FC | 0.41 | PR | 2 |
| UPN05/M/36a | DLBCL/ABC | IVA | 4 | R-CHOP×6, Radiotherapy and R-GDP×3, GDP, DICE×3 | PD | EOCH | 0.90 | SD | 2 |
| UPN06/M/44a , c | DLBCL/NOS | IIA | 2 | CHOP×6, R-CHOP×2, R-ESHAP | SD | CHOD | 0.48 | PR | (2+11)13+ |
| UPN07/F/46a , d | FL | IVA | 3 | R-CHOP×5, R-FC | PD | None | 0.93 | CR | 5 |
| UPN08/M/49a , e | MCL | IIIA | 3 | R-Hyper-CVAD×5 | SD | None | 1.01 | CR | 5 |
| UPN09/M/63a , c , d | PCMZL | IVSA | 3 | R-CHOP×4, DICE | PD | CHODE | 1.46 | SD | (3+10)13+ |
| UPN10/M/64a | DLBCL/ABC | IIB | 3 | R-CHOP×2 | PR | CHOP | 1.29 | CR | 6+ |
| UPN11/M/70a , f | DLBCL/GCB | IIIXB | 3 | R-CHOP×5, R-ICE×2, R-ESHAP×2 and Radiotherapy | PR | None | 0.47 | CR | (16+11)27+ |
Abbreviations: ABC, activated-B-like-cell; CART, Chimeric Antigen Receptor-modified T cells; CR, complete remission; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; GCB, germinal center B-cell origin; MCL, mantle cell lymphoma; PCMZL, primary cutaneous marginal zone lymphoma; PD, disease progression; PFS, progression-free survival; PR, partial remission; SD, stable disease.
Refractory.
Relapsing.
UPN06 and UPN09 received local radiotherapy at 2 and 3 months after infusion respectively, then they both got complete remission.
Bone marrow involvement.
Lost to follow-up because patient refused to come to appointments.
CART-20 infusion again in phase IIa trail after 16-month CR from our phase I trial.
+ indicates an ongoing response as of the time of manuscript submission.