Figure 1.

Performance of the model for AMD lifetime risk assessment based on 25 variables (genetic factors only). (a) Receiver operating characteristic curve (ROC) for the 25-SNP model was generated for learning (blue line) and testing (red dashed line) sets by using the binary logistic regression analysis with a 10-fold cross-validation method. (b) Prediction success parameters were calculated for testing set. AMD, age-related macular degeneration cases; NC, normal control; NPV, negative prediction value; PPV, positive prediction value.