Table 3.
Pain-related genes associated with ion channel function.49
| Gene name | Channel type affected | Pain phenotype |
|---|---|---|
| SCN9A 50 | Voltage-gated Na+ channels | ↑ Chronic pain in a mixed cohort (phantom limb, post-lumbar discectomy |
| KCNS1 | Voltage-gated K+ channels | ↑↑ Post-amputation pain |
| CACNA2D3 | Voltage-gated Ca2+ channels | ↓ Chronic postsurgical pain (discogenic) |
| CACNG2 | Voltage-gated Ca2+ channels | ↑ Chronic postsurgical pain (post mastectomy) |
SCN9A: gene coding for voltage gated sodium channel subtype 1.7; KCNS1: gene coding for potassium channel; CACNA2D3: gene coding for α2δ3 subunit of voltage dependent Ca2+channel; CACNG2: gene coding for the ς2 subunit of the voltage dependent Ca2+channel.