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Epigenetic mechanisms in CPSP and proposed sites.
| Mechanism | Site | References |
|---|---|---|
| DNA methylation | General | Doehring et al.28 |
| Prefrontal cortex | Tajerian et al.51 | |
| Histone modification | Brain stem nucleus | Zhang et al.52 |
| Spinal cord | Imai et al.53 | |
| miRNA involvement | Spinal cord | Shi et al.54 |
| Spinal cord | Lutz et al.55 | |
| PNS, spinal cord and brain | Bali and Kuner56 |
CPSP: chronic postsurgical pain; PNS: peripheral nervous system.
