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. 2017 Oct 25;9:655–668. doi: 10.2147/CEOR.S136657

Table S3.

Parameters included in the DSA

Parameters Base case value Low value High value Justification of tested values
Discounting (%) 4 0 6 HAS recommendations
Safety (reported probability of event)
Afatinib – diarrhea grade 3 0.099 0.071 0.130 95% CI
Afatinib – diarrhea grade 4 0.005 0.001 0.014 95% CI
Afatinib – rash/acne 0.059 0.038 0.084 95% CI
Afatinib – stomatitis grade 3 0.041 0.024 0.063 95% CI
Afatinib – fatigue grade 3 0.015 0.005 0.029 95% CI
Afatinib – nausea grade 3 0.010 0.003 0.022 95% CI
Erlotinib – diarrhea grade 3 0.023 0.011 0.040 95% CI
Erlotinib – diarrhea grade 4 0.003 0.0001 0.010 95% CI
Erlotinib – rash/acne 0.104 0.076 0.136 95% CI
Erlotinib – fatigue grade 3 0.018 0.007 0.033 95% CI
Erlotinib – nausea grade 3 0.008 0.002 0.019 95% CI
Utilities and disutilities
Progression-free survival utility 0.65 0.63 0.75 Low value: low value of 95% CI of two data sources (LUX-Lung 8 trial3 and Nafees et al4)
High value: high value of 95% CI of LUX-Lung 8 trial3 data source
Post-progression survival utility 0.58 0.47 0.61 Low value: Nafees et al4
High value: high value of 95% CI of LUX-Lung 8 trial3 data source
Diarrhea grade 3 disutility 0.050 0.019 0.096 95% CI
Diarrhea grade 4 disutility 0.050 0.019 0.096 95% CI
Rash/acne disutility 0.030 0.004 0.080 95% CI
Stomatitis grade 3 disutility 0.131 0.112 0.151 95% CI
Fatigue grade 3 disutility 0.070 0.036 0.114 95% CI
Nausea grade 3 disutility 0.050 0.019 0.096 95% CI
Costs (EUR)
Mean transportation cost per round-trip 77.06 64.76 89.41 Low value: estimated VSL cost
High value: estimated taxi cost
Unit cost for diarrhea grade 3 2,801.76 1,813.15 4,002.05 95% CI
Unit cost for diarrhea grade 4 2,801.76 1,813.15 4,002.05 95% CI
Unit cost for rash/acne 225.67 146.04 322.35 95% CI
Unit cost for stomatitis grade 3 569.44 303.80 670.56 95% CI
Unit cost for fatigue grade 3 570.57 369.24 815.01 95% CI
Unit cost for nausea grade 3 1,997.00 1,292.35 2,852.52 95% CI
Monthly monitoring costs in pre-progression and post-progression for all arms 253.63 202.90 304.36 ±20%

Abbreviations: CI, confidence interval; DSA, deterministic sensitivity analysis; HAS, Haute Autorité de Santé [French National Authority for Health]; VSL, véhicule sanitaire léger [ambulance transport].