Table 2.
MIC (μg/mL) and MBC/MFC (μg/mL) of CHX and MNP@CHX against different pathogens in the presence of human saliva
| Strain | CHX
|
MNP@CHX
|
|---|---|---|
| MIC/MBC or MFC/MBIC | MIC/MBC or MFC/MBIC | |
| Staphylococcus aureus (MRSA) | 32/>32/>32 | 16/16/32 |
| Enterococcus faecalis | 16/32/>32 | 16/16/32 |
| Pseudomonas aeruginosa | 4/16/32 | 4/4/8 |
| Candida albicans | 16/16/32 | 4/4/4 |
| C. albicans + S. aureus | 32/32/>32 | 8/16/16 |
| C. albicans + E. faecalis | 32/>32/>32 | 16/16/32 |
| C. albicans + P. aeruginosa | 32/>32/>32 | 8/16/16 |
Abbreviations: CHX, chlorhexidine; MBC, minimal bactericidal concentration; MBIC, minimal biofilm inhibitory concentration; MFC, minimal fungicidal concentration; MIC, minimal inhibitory concentration; MNP@CHX, magnetic nanoparticles functionalized by chlorhexidine; MRSA, methicillin-resistant Staphylococcus aureus.