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. 2017 Oct 25;10:5137–5149. doi: 10.2147/OTT.S146423

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© 2017 Wang et al. This work is published and licensed by Dove Medical Press Limited

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Overexpression of MEG3 increased the sensitivity of DDP-resistant NSCLC cells to DDP in vivo.

Notes: A549-DDP cells transfected with MEG3 or vector were subcutaneously inoculated into the right flank of nude mice, followed by intraperitoneal injection with 4 mg/kg DDP every 4 days. (A) Changes of tumor volume in nude mice bearing A549-DDP cells with MEG3 or vector. (B) Measurement of excised tumor weight. (C) qRT-PCR analysis for MEG3, miR-21-5p, and SOX7 in removed tumor masses. *P<0.05.

Abbreviations: NSCLC, non-small cell lung cancer; qRT-PCR, quantitative real-time polymerase chain reaction; SOX7, sex-determining region Y-box 7.