Table 4.
The pharmacokinetic parameters of PL(DOX) and CPPL(DOX) in tissue (n=3)
| Tissue | AUC(0–t) (h·µg/g)
|
AUC(0–∞) (h·µg/g)
|
Tmax (h)
|
Cmax (µg/g)
|
||||
|---|---|---|---|---|---|---|---|---|
| PL(DOX) | CPPL(DOX) | PL(DOX) | CPPL(DOX) | PL(DOX) | CPPL(DOX) | PL(DOX) | CPPL(DOX) | |
| Tumor | 5.775±0.636 | 7.475±0.805* | 7.619±1.765 | 9.001±1.477* | 2 | 2 | 1.116 | 1.600 |
| Heart | 1.490±0.523 | 0.850±0.229 | 1.901±0.561 | 0.931±0.228* | 2 | 2 | 0.398 | 0.202 |
| Liver | 3.823±0.350 | 6.017±0.769* | 5.738±0.793 | 8.867±0.987* | 2 | 2 | 0.910 | 1.365 |
| Spleen | 7.492±0.440 | 4.405±1.016* | 11.017±0.756 | 6.817±2.496* | 2 | 2 | 1.390 | 0.850 |
| Lung | 0.812±0.300 | 0.676±0.322 | 1.679±0.873 | 0.731±0.332 | 2 | 2 | 0.180 | 0.181 |
| Kidney | 3.530±0.474 | 4.852±0.467 | 11.845±6.423 | 15.398±1.682 | 4 | 4 | 0.607 | 0.830 |
| Brain | 0.108±0.0434 | 0.160±0.0162 | 0.155±0.0356 | 0.17±0.017 | 2 | 2 | 0.0198 | 0.0571 |
Note:
*
p<0.05, PL(DOX) served as control.
Abbreviations: PL(DOX), doxorubicin-loaded PEGylated liposomes; CPPL(DOX), doxorubicin-loaded cell-penetrating peptide-modified pH-sensitive PEGylated liposomes; AUC, area under the concentration–time curve; Tmax, time at the maximum concentration; Cmax, maximum concentration in tissue.