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. Author manuscript; available in PMC: 2017 Oct 30.
Published in final edited form as: Dev Neurobiol. 2017 Feb 24;77(4):405–418. doi: 10.1002/dneu.22427

Figure 1.

Figure 1

Internalization and trafficking pathways of TrkA. (1) Constitutive endocytosis and transcytosis to the distal axon before TrkA encounters NGF. (2) TrkA encounters NGF in the distal axon and internalizes into a signaling endosome. The signaling endosomes then traffics retrogradely to the axon. (3) The signaling endosome can then be exocytosed onto the soma membrane and re-internalized during signaling transcytosis. PSD = Postsynaptic Density. [Color figure can be viewed at wileyonlinelibrary.com]