Table 1.
Bevacizumab (N=189) |
Standard (N=170) |
Total (N=359) |
|
---|---|---|---|
Molecular subgroup | |||
Differentiated | 36 (19.0%) | 37 (21.8%) | 73 (20.3%) |
Immunoreactive | 69 (36.5%) | 53 (31.2%) | 122 (34.0%) |
Mesenchymal | 37 (19.6%) | 31 (18.2%) | 68 (18.9%) |
Proliferative | 47 (24.9%) | 49 (28.8%) | 96 (26.7%) |
Age (years) at randomization | |||
Mean (SD) | 58.1 (11.0) | 57.4 (11.2) | 57.8 (11.1) |
Range | (26.0–80.0) | (21.0–80.0) | (21.0–80.0) |
Race | |||
White | 189 (100.0%) | 167 (98.2%) | 356 (99.2%) |
Asian | 0 (0.0%) | 3 (1.8%) | 3 (0.8%) |
ECOG score | |||
0 | 77 (40.7%) | 78 (45.9%) | 155 (43.2%) |
1 | 93 (49.2%) | 83 (48.8%) | 176 (49.0%) |
2 | 19 (10.1%) | 9 (5.3%) | 28 (7.8%) |
Origin of cancer | |||
Ovary | 169 (89.4%) | 150 (88.2%) | 319 (88.9%) |
Fallopian tube | 7 (3.7%) | 7 (4.1%) | 14 (3.9%) |
Primary peritoneum | 12 (6.3%) | 12 (7.1%) | 24 (6.7%) |
Multiple sites | 1 (0.5%) | 1 (0.6%) | 2 (0.6%) |
Histology | |||
Serous | 150 (79.4%) | 127 (74.7%) | 277 (77.2%) |
Clear cell | 7 (3.7%) | 7 (4.1%) | 14 (3.9%) |
Endometrioid | 4 (2.1%) | 6 (3.5%) | 10 (2.8%) |
Mucinous | 3 (1.6%) | 2 (1.2%) | 5 (1.4%) |
Mixed | 15 (7.9%) | 21 (12.4%) | 36 (10.0%) |
Other | 10 (5.3%) | 7 (4.1%) | 17 (4.7%) |
FIGO stage | |||
I/IIA | 14 (7.4%) | 12 (7.1%) | 26 (7.2%) |
IIB/IIC | 12 (6.3%) | 11 (6.5%) | 23 (6.4%) |
III | 134 (70.9%) | 117 (68.8%) | 251 (69.9%) |
IV | 29 (15.3%) | 30 (17.6%) | 59 (16.4%) |
Outcome of surgery | |||
Optimal | 145 (76.7%) | 129 (75.9%) | 274 (76.3%) |
Sub-Optimal | 43 (22.8%) | 40 (23.5%) | 83 (23.1%) |
missing | 1 (0.5%) | 1 (0.6%) | 2 (0.6%) |
High-risk of progression* | |||
No | 130 (68.8%) | 110 (64.7%) | 240 (66.9%) |
Yes | 59 (31.2%) | 60 (35.3%) | 119 (33.1%) |
Grade | |||
1 or 2 | 46 (24.5%) | 28 (16.8%) | 74 (20.8%) |
3 | 142 (75.5%) | 139 (83.2%) | 281 (79.2%) |
Missing | 1 | 3 | 4 |
High risk of progression: suboptimal debulked stage III, inoperable Stage III, all stage IV patients.