TABLE I. Distribution of paracoccidioidomycosis patients according to the clinical aspects for each moments of antifungal therapy.
| Moments | Clinical forms | Levels of severity | Age in the admission | IDD - admission (1:) | IDD - sample collection (1:) | Follow-up (months) | Gender ratio (M:F) |
|---|---|---|---|---|---|---|---|
| M0 (n = 15) | Acute/Subacute (n = 7) | Severe (n = 6) Moderate (n = 1) |
21(8-52) | 32 (NR-512) | 32 (NR-512) | – | 1.3 |
| Chronic (n = 8) | Severe (n = 2) Moderate (n = 6) |
55(35-63) | undiluted (NR-128) | undiluted (NR-128) | – | 7.0 | |
| P value | 0.040 | 0.0038 | 0.2091 | 0.2091 | 0.2821 | ||
| M1 (n = 27) | Acute/Subacute (n = 9) | Severe(n = 8) Moderate (n = 1) |
21(8-52) | 32 (NR-512) | 64 (NR-256) | 1.0 (0.5-17) | 1.2 |
| Chronic (n = 18) | Severe (n = 6) Moderate (n = 12) |
54(35-67) | 4 (NR-128) | 4 (NR-64) | 1.5(0.75-13) | 8.0 | |
| P value | 0.0128 | 0.0005 | 0.1091 | 0.0489 | 0.5618 | 0.1358 | |
| M2 (n = 32) | Acute/Subacute (n = 8) | Severe (n = 7) Moderate (n = 1) |
24(10-85) | 128 (NR-512) | 2 (NR-128) | 9 (2-31) | 1.0 |
| Chronic (n = 24) | Severe (n = 5) Moderate (n = 18) Mild (n = 1) |
52(35-62) | 16 (NR-128) | 2 (NR-16) | 12 (3-47) | 7.0 | |
| P value | 0.0016 | 0.0123 | 0.0767 | 0.5776 | 0.3963 | 0.0469 | |
| M3 (n = 36) | Acute/Subacute (n = 9) | Severe (n = 9) | 22(8-85) | 256 (8-512) | NR | 33 (14-135) | 0.3 |
| Chronic (n = 27) | Severe (n = 8) Moderate (n = 1) Mild (n = 1) |
49(29-67) | 16 (NR-256) | NR | 30 (5-187) | 26.0 | |
| P value | < 0.0001 | 0.0013 | 0.0004 | – | 0.5962 | < 0.0001 | |
| M4 (n = 42) | Acute/Subacute (n = 8) | Severe (n = 6) Moderate (n = 12) |
26(10-38) | 16 (NR-256) | NR | 54 (15-102) | 0.6 |
| Chronic (n = 34) | Severe (n = 10) Moderate (n = 23) Mild (n = 2) |
46(29-72) | 16 (NR-512) | NR | 60 (15-180) | 16.0 | |
| P value | 0.0369 | < 0.0001 | 0.8331 | – | 0.8854 | 0.0012 |
The comparisons were performed between acute/subacute form (AF) and chronic form (CF) patients. The comparison of levels of severity and gender ratio was performed using the Chi-Square test or the Fisher's exact test and for the others parameters, Mann-Whitney U test. Some patients were evaluated in two or more moments.