Table 2.
Association between the 50 bp Ins/Del genetic polymorphism at promoter region of the SOD1 and risk of heroin dependence
| Genders/Genotypes | Controls N (%) | Cases N (%) | Crud | Adjusted | ||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | |||
| Both genders | ||||||||
| Ins/Ins | 590 (73.8) | 328 (74.2) | 1.0 | - | - | 1.0a | - | - |
| Ins/Del | 188 (23.5) | 102 (23.1) | 0.97 | 0.74–1.28 | 0.863 | 0.96 | 0.73–1.28 | 0.827 |
| Del/ Del | 21 (2.6) | 12 (2.7) | 1.02 | 0.49–2.11 | 0.941 | 1.01 | 0.49–2.09 | 0.969 |
| Males | ||||||||
| Ins/Ins | 486 (73.4) | 297 (74.3) | 1.0 | - | - | 1.0b | - | - |
| Ins/Del | 159 (24.0) | 91 (22.7) | 0.93 | 0.69–1.25 | 0.663 | 0.94 | 0.70–1.26 | 0.660 |
| Del/ Del | 17 (2.6) | 12 (3.0) | 1.15 | 0.54–2.45 | 0.707 | 1.16 | 0.55–2.46 | 0.702 |
| Females | ||||||||
| Ins/Ins | 104 (75.9) | 31 (73.8) | 1.0 | - | - | 1.0b | - | - |
| Ins/Del | 29 (21.2) | 11 (26.2) | 1.23 | 0.57–2.83 | 0.556 | 1.27 | 0.57–2.83 | 0.559 |
| Del/ Del | 4 (2.9) | - (0.0) | - | - | - | - | - | - |
aAdjusted ORs for age and gender of participants
bAdjusted ORs for age of participants