Table 1.
Serum lipids in dams (gestation week 2) and newly weaned offspring (postnatal day 21) from mothers fed a chow diet, the chow diet supplemented with cholesterol (CH), or cholesterol and phytosterol (CH/PS) during gestation and lactation
| Endpoint | Chow | CH | CH/PS |
|---|---|---|---|
| Maternal lipids (mmol/L), gestation week 2 | |||
| Total-C | 3.73 ± 0.51a | 6.36 ± 1.23b | 4.23 ± 0.34a |
| Triglycerides | 0.61 ± 0.02a | 0.78 ± 0.09b | 0.60 ± 0.02a |
| Offspring lipids (mmol/L), postnatal day 21 | |||
| Total-C | 10.9 ± 0.4a | 12.5 ± 0.5b | 9.4 ± 0.3c |
| LDL-C | 2.6 ± 0.1a | 3.62 ± 0.1b | 1.88 ± 0.1c |
| HDL-C | 0.60 ± 0.0a | 0.67 ± 0.1a | 0.53 ± 0.0a |
| Triglycerides | 1.13 ± 0.0a | 2.09 ± 0.4b | 1.22 ± 0.1a |
| Offspring lipoprotein particle number (µmol/L), postnatal day 21 | |||
| Total LDL Particles | 378.1 ± 27.7a | 676.3 ± 114.0b | 442.5 ± 28.5a |
| Total HDL Particles | 12.3 ± 0.5a | 16.3 ± 1.6b | 11.5 ± 0.5a |
| Total VLDL Particles | 217.9 ± 9.9a | 292.4 ± 9.2b | 201.3 ± 6.7a |
a, b, cGroups not sharing a superscript are significantly different (p < 0.05). Data are mean ± SE; n = 8 chow, n = 8 CH, n = 7 CH/PS