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. Author manuscript; available in PMC: 2018 Sep 19.
Published in final edited form as: Immunity. 2017 Sep 19;47(3):481–497.e7. doi: 10.1016/j.immuni.2017.09.001

Figure 6.

Figure 6

High cell concentrations of Irf4 directs Teff cell fate independently of IL-2 signaling. (A) Immunization scheme of Irf4-inducible (Irf4+/+) OT-II TCR Tg CD4+ T cells (CD45.2+, Rag1−/−), congenic CD45.1+ hosts, RFP-OVA antigen, ± anti-IL2 treatment, and ± DOX treatment during the first two days of immunization only. 5 days after immunization, donor cells (CD45.1−B220−MHCII−CD45.2+CD4+) were analyzed. Contour plots (B) and frequencies, mean±SD (C) of the indicated PD-1 and CXCR5 populations; contour plots (D) and frequencies, mean±SD (E) of the indicated Tbet and Bcl6 populations; Experiments in B–E are from 6 mice in 2 experiments; contour plots are concatenated files from all mice of a given group in a given experiment. See also Figure S6.