TABLE 2.
Cytokine, Chemokine, and IgE Analysis of 30 DoDSR Serum Samples
| Analyte | Mean ± SD (pg/mL) | Median | Lower Quartile | Upper Quartile | Ref Sample* Mean (pg/mL) |
|---|---|---|---|---|---|
| Eotaxin | 115.6 ± 46.1 | 83.4 | 83.4 | 147.1 | 115.5 |
| G-CSF | 41.9 ± 30.3 | 21.8 | 21.8 | 49.9 | 43.5 |
| Flt3-L | 12.4 ± 20.3 | 0.3 | 0.3 | 15.6 | 55.7 |
| GM-CSF | 7.7 ± 10.0 | 1.0 | 1.0 | 11.9 | 15.1 |
| Fractalkine | 73.4 ± 71.0 | 28.7 | 28.7 | 94.5 | 135.2 |
| IFNγ | 13.4 ± 19.3 | 2.1 | 2.1 | 12.3 | 28.8 |
| GRO | 896.3 ± 810.9 | 517.8 | 517.8 | 833.2 | 1170.1 |
| IL-10 | 10.4 ± 15.1 | 0.3 | 0.3 | 15.0 | 5.2 |
| IL-12p40 | 33.8 ± 53.2 | 0.3 | 0.3 | 50.2 | 18.1 |
| IL-12p70 | 2.3 ± 2.9 | 0.3 | 0.3 | 3.0 | 2.5 |
| IL-13 | 8.9 ± 16.3 | 0.3 | 0.3 | 13.7 | 13.1 |
| sCD40L | 1061.9 ± 856.0 | 330.9 | 330.9 | 1393.2 | 3934.8 |
| IL-17A | 10.7 ± 29.0 | 1.9 | 1.9 | 7.4 | 11.9 |
| IL-1ra | 35.7 ± 51.0 | 3.8 | 3.8 | 50.6 | 41.6 |
| IL-1α | 15.5 ± 24.9 | 0.3 | 0.3 | 24.0 | 22.2 |
| IL-1β | 4.4 ± 5.7 | 0.3 | 0.3 | 8.0 | 2.8 |
| IL-5 | 1.6 ± 2.9 | 0.3 | 0.3 | 1.0 | 1.0 |
| IL-6 | 5.1 ± 7.3 | 0.3 | 0.3 | 7.2 | 7.6 |
| IL-8 | 79.0 ± 70.0 | 37.7 | 37.7 | 89.9 | 14.0 |
| MCP-1 | 646.3 ± 258.1 | 463.9 | 463.9 | 756.9 | 504.6 |
| TNFα | 7.2 ± 3.4 | 5.0 | 5.0 | 9.9 | 5.8 |
| VEGF | 197.0 ± 218.3 | 68.0 | 68.0 | 236.5 | 239.9 |
| IgE | 482.1 ± 893.6 | 196.8 | 49.9 | 518.1 | N/A |
Cytokine and chemokine levels were determined by a multiplex immunosorbent assay. IgE levels were determined by ELISA. The mean amount of each serum component detected ±the standard deviation across all samples is shown in column 2. Then, columns 3 to 6 show median value, lower, and upper quartiles.
*
Column 7 is the mean values obtained from internal, freshly isolated serum samples (n =3).
G-CSF, Granulocyte-colony stimulating factor; GM-CSF, Granulocyte-macrophage colony-stimulating factor; GRO, Growth related oncogene; IFN, Interferon; MCP, monocyte chemoattractant protein; TNF, Tumor necrosis factor; VEGF, Vascular endothelial growth factor.