Table 1.
Baseline Characteristics of Patients According to Quartiles of HDL at 6 Months
| Quartile 1 <34.8 mg/dl |
Quartile 2 34.9 to <40.7 mg/dl |
Quartile 3 40.7 to <48.0 mg/dl |
Quartile 4 48.0 to 94.0 mg/dl |
Overall 12.0 to 94.0 mg/dl |
|
|---|---|---|---|---|---|
| Characteristic | (N = 551) | (N = 545) | (N = 538) | (N = 558) | (N = 2192) |
| Assigned to PCI + OMT, n | 265 | 280 | 273 | 282 | 50.2 (%) |
| Assigned to OMT, n | 286 | 265 | 265 | 276 | 47.8 (%) |
| Male, % | 94.6 | 91.2 | 86.8 | 69.4 | 85.4 |
| White, % | 89.8 | 84.0 | 84.6 | 87.7 | 86.6 |
| Current smoker | 35.6 | 26.7 | 27.8 | 22.6 | 28.1 |
| Body mass index, kg/m2 | 30.8 ± 5.2 | 30.2 ± 5.0 | 29.2 ± 4.6 | 28.1 ± 4.8 | 29.6 ± 5.0 |
| Age, yrs | 60.9 ± 10.1 | 61.4 ± 10.0 | 61.8 ± 9.7 | 64.1 ± 9.4 | 62.0 ± 9.9 |
|
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| Cardiovascular history, % | |||||
| Myocardial infarction | 42.0 | 37.9 | 37.7 | 37.8 | 38.9 |
| Prior CABG | 14.2 | 9.4 | 10.4 | 10.2 | 11.0 |
| Prior PCI | 21.0 | 13.0 | 13.8 | 14.2 | 15.5 |
| Stroke | 6.0 | 5.9 | 4.1 | 3.6 | 4.9 |
| Peripheral vascular disease | 9.3 | 7.4 | 6.8 | 7.2 | 7.7 |
| Hypertension | 74.2 | 69.1 | 62.3 | 63.2 | 67.3 |
| Heart failure | 4.2 | 5.5 | 3.7 | 4.0 | 4.4 |
| Diabetes | 41.4 | 33.4 | 32.1 | 28.0 | 33.7 |
| Angina | 89.1 | 89.2 | 87.3 | 85.7 | 87.8 |
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| Drugs at study entry, % | |||||
| Statin | 67.0 | 68.6 | 67.1 | 67.4 | 67.5 |
| Other anti-lipid drugs | 9.6 | 7.6 | 4.1 | 5.1 | 6.6 |
| Calcium blocker | 31.9 | 32.7 | 29.2 | 28.8 | 30.7 |
| ACEI or ARB | 45.7 | 45.3 | 48.1 | 49.6 | 47.1 |
| Beta blocker | 73.0 | 72.9 | 69.9 | 68.5 | 71.1 |
| Nitrates | 60.1 | 60.5 | 57.1 | 53.8 | 57.9 |
| Aspirin | 87.3 | 88.6 | 89.0 | 85.7 | 87.6 |
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| Lipid values at 6 months, mg/dl | |||||
| LDL-C | 81.2 ± 27.6 | 85.0 ± 26.2 | 88.5 ± 25.8 | 88.9 ± 28.7 | 85.9 ± 27.3 |
| HDL-C | 30.6 ± 3.3 | 37.7 ± 1.7 | 43.8 ± 2.0 | 57.4 ± 9.1 | 42.4 ± 11.1 |
| Total-C | 148.3 ± 34.5 | 154.0 ± 32.2 | 160.3 ± 32.6 | 170.7 ± 32.8 | 158.4 ± 34.1 |
| Triglycerides | 197.2 ± 128.2 | 160.6 ± 86.8 | 148.6 ± 101.5 | 125.9 ± 67.6 | 158.0 ± 101.7 |
| LDL-C to HDL-C | 2.7 ± 1.0 | 2.3 ± 0.7 | 2.0 ± 0.6 | 1.6 ± 0.6 | 2.1 ± 0.8 |
| Total-C to HDL-C | 4.9 ± .13 | 4.1 ± 0.9 | 3.7 ± 0.8 | 3.0 ± 0.7 | 3.9 ± 1.2 |
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| Anti-lipid drugs at 6 months, % | |||||
| Statin | 92.6 | 94.4 | 95.5 | 94.2 | 94.2 |
| Other lipid lowering | 35.4 | 27.4 | 20.1 | 16.2 | 24.7 |
Values are n, %, or mean ± SD.
ACEI = angiotensin-converting-enzyme inhibitor; ARB = angiotensin receptor blockers; CABG = coronary artery bypass grafting; HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; OMT = optimal medical therapy; PCI = percutaneous coronary intervention.