. Author manuscript; available in PMC: 2017 Oct 30.

Published in final edited form as: Am J Surg Pathol. 2009 Dec;33(12):1752–1764. doi: 10.1097/PAS.0b013e3181b8cf03

Table 1.

Martini and Melamed criteria to define multiple primary non-small cell lung cancer (adapted from [6]).

Synchronous multiple tumors

TUMOR LOCATION	HISTOLOGICAL TYPE
TUMOR LOCATION	SIMILAR	DIFFERENT
Same segment	metastasis	multiple primary
Different segment	- Origin from carcinoma in situ, and no carcinoma in lymphatics common to both, and no systemic metastasis: multiple primary	multiple primary
	- No carcinoma in situ, or carcinoma in lymphatics common to both, or systemic metastasis: metastasis	multiple primary

Metachronous multiple tumors

TIME INTERVAL	TUMOR LOCATION	HISTOLOGICAL TYPE		FOCI OF CARCINOMA IN SITU
TIME INTERVAL	TUMOR LOCATION	SIMILAR	DIFFERENT	FOCI OF CARCINOMA IN SITU
≥ 2 years		multiple primary	multiple primary	multiple primary
< 2 years	Same lobe	metastasis	multiple primary	multiple primary
	Different lobe	- No carcinoma in lymphatics common to both, and no systemic metastasis: multiple primary	multiple primary	multiple primary
		- Carcinoma in lymphatics common to both, or systemic metastasis: metastasis	multiple primary	multiple primary