Table 3.

Comparison of comprehensive histologic assessment with Martini-Melamed criteria and molecular characterization.

Case	Martini-Melamed	Molecular consensus	Comprehensive histologic review
			frozen	paraffin
1	multiple primary	multiple primary	different	different
2	multiple primary	multiple primary	similar	different
3	multiple primary	multiple primary	different	different
4	multiple primary	multiple primary	similar	different
5 (A vs. B)	multiple primary	multiple primary	different	different
5 (A vs. C)*	multiple primary	metastases	different	different
5 (B vs. C)	multiple primary	multiple primary	different	different
6	metastases	metastases	similar	similar
7	multiple primary	metastases	similar	similar
8	multiple primary	multiple primary	different	different
9	multiple primary	metastases	similar	similar
10	multiple primary	multiple primary	n/a	different
11	multiple primary	unknown	different	different
12	multiple primary	multiple primary	similar	different
13	multiple primary	metastases	similar	similar
14	multiple primary	multiple primary	different	different
15	multiple primary	multiple primary	n/a	different
16	multiple primary	multiple primary	different	different
17	multiple primary	multiple primary	different	different
18	multiple primary	unknown	different	different
19*	metastases	multiple primary	different	similar
20 (A vs. B)	multiple primary	metastases	similar	similar
20 (B vs. C)	metastases	metastases	similar	similar
20 (A vs. C)	multiple primary	metastases	similar	similar

^*indicates discrepancies between the comprehensive histologic assessment and the molecular consensus.