Table 3.
Myelination Genes Revealed by Forward Genetic Screening in Zebrafish
| Allele | Gene (If Known) | Myelinating Glia Phenotype | Function | Screen/Citation |
|---|---|---|---|---|
|
| ||||
| st14, st48 | erbb3b | Reduced mbp in LLn | Nrg/Erb signaling | Lyons et al. (2005) |
| st50, st61 | Erbb2 | Reduced mbp in LLn | Nrg/Erb signaling | Lyons et al. (2005) |
| st20 | Foxa2 | Reduced mbp in hindbrain | Forkhead transcription factor | Norton et al. (2005) |
| st47 | Reduced mbp in CNS | Pogoda et al. (2006) | ||
| st64 | Reduced mbp in ALLn | Pogoda et al. (2006) | ||
| i26 | aldh1a2 | PLLn amyelination | Aldehyde dehydrogenase | Kazakova et al. (2006) |
| M807 | Med12 | PLLn/CNS amyelination | Transcription mediator complex subunit | Kazakova et al. (2006) |
| tm79a | dzip1 | Loss of mbp in posterior PLLn | DAZ interacting zinc finger protein, regulator of Hedgehog signaling | Kazakova et al. (2006) |
| tt258 | Loss of mbp in posterior PLLn | Kazakova et al. (2006) | ||
| st25, st53 | Nsfa | Reduced mbp in LLn and CNS | N-ethylmaleimide-sensitive factor, synaptic vesicle fusion | Woods, Lyons, Voas, Pogoda, and Talbot (2006) |
| st60 | aII-spectrin | Reduced mbp in PNS/CNS | Cortical cytoskeleton component | Voas et al. (2007) |
| st23 | Kbp | Reduced mbp in LLn, CNS amyelination | Intracellular transport | Lyons, Naylor, Mercurio, Dominguez and Talbot (2008) |
| st49, st63 | adgrg6/gpr126 | PNS amyelination | GPCR Gas signaling | Monk et al. (2009) |
| st43 | kif1b | Reduced mbp in LLn, punctate mbp in CNS | mRNA transport | Lyons, Naylor, Scholze, and Talbot (2009) |
| vu56 | fbxw7 | Excess CNS myelination | F-box subunit of E3 ubiquitin ligase | Kearns et al. (2015) and Snyder et al. (2012) |
| vu76 | dync1h1 | Reduced PNS myelination; reduced OPCs | Dynein heavy chain subunit | Langworthy and Appel (2012) and Yang et al. (2015) |
| vu166 | Pescadillo | Reduced OPCs | Ribosome biogenesis, cell proliferation | Simmons and Appel (2012) |
| st67 | sec63 | Reduced PLLn and CNS myelination | ER translocon machinery | Monk et al. (2013) |
| st51 | notch3 | Reduced mbp in CNS | Notch signaling | Zaucker et al. (2013) |
| vu57 | hmgcs1 | OPC migration defects, reduced CNS mbp | Isoprenoid and cholesterol synthesis | Mathews et al. (2014) |
| st78 | znf16l | Reduced mbp in CNS | Zinc finger transcription factor | Sidik and Talbot (2015) |