Table 1.

New antigens added to blood group systems

Blood group system	Antigen number	Alt. name	Prevalence	Molecular basis	Protein change
MNS	MNS47	SARA	Low	GYPA c.240G>T	p.Arg80Ser
MNS	MNS48	KIPP	Low	GYP(B-A-B) hybrid	p.Ser51a GPB(1-26)-GPwB(27-54)-GPA(55-57)-Bs(58-103)
LU	LU23	LUIT	High	LU c.469G>A, 1289C>T	p.Gly157Arg, p.Thr430Ile
LU	LU24	LUGA	High	LU c.212G>A	p.Arg71His
DO	DO9	DOLC	High	ART4 c.566C>T	p.Thr189Met
DO	DO10	DODE	High	ART4 c.405C>A	p.Asp135Glu
GLOB	GLOB2	PX2	Highb	B3GALNT1	c
Vel	VEL1	Vel	High	SMIM1 c.64_80delGTCAGCCTAGGGGCTGT	p.Ser22Glnfs*270
CD59	CD59.1	–	High	CD59 c.146delA	p.Asp49Valfs*31
AUG	AUG1	–	High	ENT1 c.589 + 1G>C	p.Ser197fs
AUG	AUG2	Ata	High	ENT1 c.1171G>A	p.Glu391Lys

^aDistinguishes this protein from other known GP(B-A-B) hybrids.

^bAlthough PX2 is a product of β1,3GalNAc-T1 and therefore present on RBCs of common phenotype, it is absent from RBCs of ${\mathrm{P}}_1^{\mathrm{k}}$ and ${\mathrm{P}}_2^{\mathrm{k}}$ phenotypes whilst highly expressed on RBCs of the p phenotype.

^cThus, all mutations causing the of ${\mathrm{P}}_1^{\mathrm{k}}$ and ${\mathrm{P}}_2^{\mathrm{k}}$ phenotypes also cause lack of PX2.