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. 2017 Oct 30;15:193. doi: 10.1186/s12916-017-0954-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Flow diagram of the selection of trials for second-line treatments in advanced NSCLC with wild-type or unknown status for EGFR. ° Details in Appendix 6; * Additional articles not identified by searching bibliographic databases; ^$ 5 trials (10 reports) with chemotherapy (i.e., docetaxel or pemetrexed) at the investigators’ discretion. The last search for randomized trials was conducted on June 6, 2017