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. Author manuscript; available in PMC: 2018 Jun 14.
Published in final edited form as: J Phys D Appl Phys. 2017 May 17;50(23):233002. doi: 10.1088/1361-6463/aa6e18

Figure 2. Soft melanoma tumor-repopulating cells extravasate efficiently to secondary sites of metastasis.

Figure 2

The melanoma tumor-repopulating cells (TRCs) are injected into the pericardial cavity (to the left of the image, not shown) of a zebrafish. The undifferentiated soft TRCs arrest at the tail and squeezed out of the small blood vessel (green color) more efficiently than the differentiated stiff control melanoma cells. The efficient extravasation of the soft TRCs and the ensuing micrometastasis formation and metastatic colonization is inhibited by differentiating the TRCs with retinoic acid, stiffening F-actin with a polymerizing drug, or promoting F-actin via overexpressing small GTPase Cdc42 (from [93]).