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The three phases of bone healing. COX-2 = cyclooxygenase-2; IL1,6 = interleukin 1 & 6; M1 = M1 macrophages; M2 = M2 macrophages; MΦ = macrophage; MSCs = mesenchymal stem cells; PGE2 = prostaglandin E2; RANKL = receptor activator of nuclear factor kappa-B ligand.
