Table 1.
Genes involved in methyl-pool/C1 metabolism with LRH-1 binding sites.
| Gene | TSS2pCenter | Gene | TSS2pCenter |
|---|---|---|---|
| Ada | - | Mthfd1 | −6 |
| Adk | - | Mthfd2 | +8330 |
| Ahcy | −4191 | Mthfr | −28|+2084 |
| Amd2 | −1145|+132 | Mthfs | - |
| Bhmt | −138 | Mtr | - |
| Bhmt2 | −18 | Mtr | - |
| Cbs | - | Pemt | −8721|9507 |
| Chdh | −3363|−9427|+13|+2876|+4206|+8940 | Sgms1 | −721|+1079 |
| Cth | +411 | Smpd1 | −66 |
| Dhfr | - | Srm | −201 |
| Gamt | −58|−5241|+3822|+9964 | Tyms | −124 |
| Gnmt | −79|−4161|+6930 | ||
| Mars1 | −40 | Nr0b2 | −209|−4217|−9950 |
| Mars2 | −54 | Cyp8b1 | −591−3536 |
| Mat1a | −7795 | Mdr2 | −238|−4727|−8665 |
| Mat2a | +5799 |
Note. The LRH-1 ChIP-Seq dataset published by Chong et al. (16) was used to screen for LRH-1 binding sites within 10kb of the transcription start site. Since there is no gene ontology category for C1 metabolism we used genes regarded to play key roles in C1 metabolism according to recent comprehensive reviews (1, 2). TSS2pCenter, transcription start site to center of peak.