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. Author manuscript; available in PMC: 2017 Oct 30.
Published in final edited form as: Cell Rep. 2016 Jun 16;16(1):106–119. doi: 10.1016/j.celrep.2016.05.080

Figure 6.

Figure 6

IL-6 complexes with sIL-6R to induce TRPV1 gene expression in a STAT3-dependent manner in DRG neurons. (A) Representative immunofluorescence staining of pSTAT3 in DRGs isolated form WT mice treated with control buffer, IL-6, sIL-6R, IL-6+sIL-6R, IL-6+sIL-6R+gp130Fc, IL-6+sIL-6R+IgGFc. Right panel: the fraction of DRG cells stained with pSTAT3 (*P<0.05, **P<0.05, n=6), scale bar 50μm. (B) TRPV1 mRNA levels were increased in DRG cells isolated from WT mice treated for 24 hours with IL-6+sIL-6R together but not separately. TRPVI mRNA levels were reduced by pretreatment with gp130Fc or Statics, a pSTAT3 inhibitor (*P<0.05, **P<0.01).