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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Eur J Pharmacol. 2017 Oct 5;815:33–41. doi: 10.1016/j.ejphar.2017.10.006

Fig. 3. Impact of CORM-2 on Kv11.1 mutant and Kv11.3.

Fig. 3

A) Multiple sequence alignment of part of the S5–S6 loop of Kv11.1, Kv10.1, and Kv11.3; histidines in Kv11.1 that were mutated are highlighted. B) Representative current traces for the indicated pulse protocols for Kv11.1-HD:HY (Kv11.1-H578D:H587Y, left) and Kv11.3 (right) channels in the whole-cell configuration before (black) and 300 s after application of 50 µM CORM-2 (red). C) Mean relative remaining current for the indicated channel variants after CORM-2 application. Data are means ± S.E.M. with n indicated in parentheses; ***P<0.001 difference compared with hERG1 (wild type).