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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Eur J Pharmacol. 2017 Oct 5;815:33–41. doi: 10.1016/j.ejphar.2017.10.006

Fig. 4. Peptide modification by CORM-2.

Fig. 4

A) HPLC elution profiles of 22mer peptides corresponding to the pore loop sequences of wild-type Kv11.1 channels (wt, (1)) or its double mutant H578D:H587Y (HD:HY, (4)). Colored traces are from peptides preincubated with CORM-2, black: peptides without preincubation. The elution peak for the non-modified peptides is marked with an asterisk. B) Mass spectra of wild-type and double-mutant peptides (as in (A)) before (black) and after incubation with CORM-2 (red). The labeled peaks correspond to (M+4H+)4+, (M+3H+)3+ and (M+2H+)2+ of the peptides or the peptide:Ru(CO)2 complexes.