Fig 4. Effect of change in asymmetric differentiation and plasticity rates on survivability of mutants.

Subfigures show the variation of ρ_S with respect to the relative fitness of mutants r, in which we start with an initial mutant within SCs. We assume that N_S = N_D = 10, $r_1={\tilde{r}}_1=1,$ and $r_2={\tilde{r}}_2=r$. In subfigure (a), the fixation probability of SCs as a function of η is given, where η = 0.01, 0.1, 0.5 while u₁ = u₂ = 0.5, and η₁ = 0. In (b) η₁ = 0 and η = 0.1. Changing parameters u₁ and u₂, which are the asymmetric division rates of normal and tumor SCs respectively, the fixation probability as a function of u₁, u₂ is shown. Solid lines represent the exact calculation and points correspond to simulation results (error bars are based on the standard error of the mean).