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Model describing how ligation of α5β1-integrin synergy site promotes MEC malignancy. When tumor cells encounter FN-rich, stiff collagen fibers at invasive fronts, they engage the α5β1-integrin synergy site to recruit vinculin and zyxin to sites of focal adhesions in a tension-dependent manner to nucleate PIP3 at the plasma membrane and enhance PI3K–dependent tumor cell invasion.
