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. 2017 Jul-Sep;9(3):55–63.

Fig. 1.

Fig. 1

Structures of death receptors. Death receptors and their ligands include: receptors DR4 (TNFRSF10A, TRAIL-R1), DR5 (TNFRSF10B, TRAIL-R2, Apo2), DcR1 (TRAILR3), and DcR2 (TRAILR4) and their ligand, TRAIL; the tumor necrosis factor receptor (TNFR) and its ligand, the tumor necrosis factor (TNF); the Fas receptor (CD95, Apo1) and its ligand, FasL. Note: TRADD – the tumor necrosis factor receptor type 1-associated death domain protein; FADD – the Fas-associated death domain protein; DD – a death domain; DED – a death effector domain; RIP – a receptor-interacting protein.