Table 3.
Clusters showing significant changes in grey matter surface area in patients with obsessive–compulsive disorder
| Cluster | Max t-value | VtxMax | Cluster size, mm2 | VtxMax Talairach coordinates, x, y, z | CWP p value (90% CI) | NVtxs |
|---|---|---|---|---|---|---|
| Left hemisphere | ||||||
| Lateral occipital cortex, superior-inferior parietal cortex | −3.941 | 87 140 | 2971.33 | −26.9, −85.3, 18.4 | 0.0006 (0.0003–0.0009) | 4014 |
| Superior parietal cortex, precuneus, posterior cingulate | −3.568 | 14 332 | 2422.88 | −7.4, −48.9. 59.8 | 0.002 (0.001–0.003) | 5152 |
| Rostral middle frontal cortex, pars triangularis, pars orbitalis, pars opercularis | −2.681 | 84 578 | 1701.91 | −46.6, 30.5, 9.2 | 0.025 (0.023–0.027) | 2384 |
| Right hemisphere | ||||||
| Rostral middle frontal cortex, pars triangularis, pars orbitalis, lateral orbitofrontal cortex | −4.278 | 58 399 | 2293.91 | 42.0, 41.8, 0.0 | 0.006 (0.005–0.007) | 3159 |
| Precuneus, isthmus cingulate | −4.237 | 156 055 | 1690.44 | 8.6, −50.4, 24.6 | 0.030 (0.028–0.032) | 3705 |
| Middle-inferior temporal cortex, banks of the superior temporal sulcus, fusiform gyrus | −3.844 | 59 310 | 2007.95 | 66.6, −31.2, −5.9 | 0.012 (0.010–0.013) | 3124 |
| Superior-inferior parietal cortex, lateral occipital cortex, cuneus | −2.720 | 104 620 | 2201.18 | 34.3, −78.3, 19.9 | 0.007 (0.006–0.008) | 3436 |
CI = confidence interval; CWP = cluster-wise probability; NVtx = number of vertices in cluster; VtxMax = no. of peak vertices of the significant cluster.
*
Annotation of clusters according to the FreeSurfer atlas.