Table 4. Renal function and renal pathology at baseline and post-Treg infusion.

The Banff i-scores and t-scores represent the degree of mononuclear cell infiltration in the interstitium and tubules respectively seen on light microscopy. Quantitative image analysis of immunohistochemical staining for CD45 was used to calculate the density of overall inflammation.

	Kidney biopsy time point	Kidney transplant function			Histopathology		Immunohistochemistry
		Serum creatinine (mg/dl)	Estimated GFR (ml/min/1.73m2)	Urine protein/ creatinine (mg/g)	Banff i-score	Banff t-score	LCA+ cells/mm2
Subject 1	Baseline	1.30	56	170	1	1	337.2
	2 weeks	1.37	53	160	0	0	18.9
	6 months	1.38	54	NA*	0	0	126.1
Subject 2	Baseline	1.55	49	120	0	1	469.1
	2 weeks	1.53	49	90	0	0	303.5
	6 months	1.49	51	90	0	1	74.9
Subject 3	Baseline	1.32	64	200	0	1	278.0
	2 weeks	1.37	61	220	1	1	454.4
	6 months	1.27	67	270	2	2	514.0

^*Lab unable to calculate urine protein/creatinine as urinary protein concentration was <6 mg/dl.